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Sysmex XE-5000

XE-5000

  • Fluorescence flow cytometry, excellent WBC differential and standardised body fluid analysis
  • Extremely fast with low turnaround times
  • Gold standard technology for reticulocytes (RET, IRF, RET-He)
  • Valuable information with diagnostic impact – NRBC and IG counting, IPF and immature myeloid information including HPC counting
  • Expandable as total laboratory solution and proactive user support

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XE-5000 – X-Class flagship, advanced parameters and body fluids

Our XE-5000 differential analyser is our flagship X-Class analyser. It brings together as standard the best of our technology from the XE-2100 with even stronger analytical power and clinical value. Its fluorescence flow cytometry analysis technology delivers accuracy and precision never achieved before. Because it's extremely fast, processing up to 150 samples per hour, you can deliver results more quickly and greatly enhance the productivity of your lab.

The accuracy and clinical utility of our instruments are renowned around the world. The XE-5000 offers a 5-part differential plus NRBC and IG count as standard. High-quality standard parameters for red blood cells make it easier to detect and screen anaemia. And hydrodynamic focusing in the RBC/PLT channel delivers a red blood cell parameter profile and haematocrit values in line with the ICSH reference methods. This level of accuracy and versatility opens doors for more powerful clinical utility and better patient support.

With the special XE-5000 Case Manager, our top X-Class analyser can contribute to making your life in the laboratory easier and more effective than before. By looking beyond individual parameter results to more specific parameter combinations involving advanced clinical parameters, it will direct your attention to abnormalities. This supports a shortening in diagnosis time – which has to be good news for the patient.  

Haematology

Breakthrough technologies for remarkable accuracy

Breakthrough technologies for remarkable accuracy

We’ve been producing haematology analysers for over 40 years, and this is one of our best. The most important matter in any laboratory is the ability to detect pathological samples. The XE-5000 combines various technologies to deliver remarkable accuracy and reliability.

Its automated white blood cell differential technology will help you significantly reduce the number of smear reviews. Innovative fluorescence flow cytometry technology for white cell differentials delivers unique accuracy and precision never achieved before.

The XE-5000 includes other breakthrough technologies, like hydrodynamic focusing in the RBC/PLT channels. This delivers a precise red blood cell parameter profile and haematocrit value that correlates perfectly with the ICSH reference methods. And its complete parameter panel for screening red cell disorders is based on high-quality standard parameters for red blood cells.

Fast and helpful

Fast and helpful

The XE-5000 reduces turnaround times to a real minimum and reaches impressive throughput rates. It delivers up to 150 samples per hour in the CBC+DIFF+NRBC profile and even total cell profiles are processed at rates of 113 samples/h.

The XE-5000 is a comprehensive analyser with a standard 5-part differential plus true NRBC and IG counting. The FDA (Food and Drug Administration), for instance, has confirmed excellent correlation to the reference method for the reportable Immature Granulocyte (IG) measurement. Since there is better differentiation between the subpopulations, your or your staff’s workload can be decreased significantly.

Thanks to its range of technologies, diagnostic security and throughput rate, the XE-5000 can help to improve the productivity and clinical utility and address the profitability of almost any laboratory.

Advanced clinical parameters as standard

Advanced clinical parameters as standard

The XE-5000 with its Case Manager has advanced clinical parameters on board as standard, including IG count, IPF, RET-He and HPC analysis . With this range of diagnostic parameters in the device, it looks beyond individual parameter results to more specific parameter combinations. If it encounters a positive match, and therefore a potential abnormality, the Case Manager alerts the user.

By generating and analysing this additional information, it can potentially shorten the time between detecting an abnormality and its diagnosis. This can benefit both the recovery of the patient and the reputation of the lab. 

Body Fluids

Body Fluids

On board as standard, the XE-5000 can perform standardised body fluid (BF) analysis. This eliminates the variability of manual microscopy analysis. It measures several human body fluids including CSF, serous fluids, and synovial fluid

Because analysis is quick, automated and standardised directly from the sample tube, you can now easily include BF analysis in your existing workflow. Thanks to the true counting method, results can be trusted and decisive. They support further diagnosis by including a total nucleated cell count and differentiating mononuclear and polymorphonuclear white blood cells.   

Diagnostic utility

Diagnostic utility

  • NRBC counting

The XE-5000 offers precise and accurate NRBC counting. Because it counts instead of flagging, it improves the accuracy of the WBC count and WBC differential count by using a separate channel and specialised reagent system. This is useful for neonates, and for a variety of blood cell disorders. You or your lab staff will have to spend less time behind the microscope as you can avoid the tedious correction of a WBC count by visual microscopy. And critical developments, for instance with intensive care patients, may be detected at an earlier point in time.

  • Understanding haemopoietic system activity

The IMI channel, when run in a dedicated HPC mode, can be used to provide HPC counts quickly and reliably when monitoring patients undergoing peripheral blood stem cell harvesting by detecting even the lowest concentrations of myeloid precursors.

In addition, in many clinical conditions, accurately determining the reticulocyte differential reveals initial results of a therapy’s success. For example, the XE-5000 delivers accurate and valuable IRF and RET-He information that opens up new clinical areas for patient management. The red cell profile alongside the reticulocyte differential will help you better assess the erythropoietic system status.

  • Immature reticulocyte fraction (IRF)

In the XE-5000, reticulocytes are fractionated according to their fluorescence intensity into three categories – low (LFR), medium (MFR) and high fluorescence reticulocytes (HFR) - representing different maturity stages. The IRF is the ratio of immature retics with medium and high fluorescence activity (MFR + HFR) to total reticulocytes. This parameter is proving valuable for predicting bone marrow suppression and the recovery of erythropoiesis.

  • RET-He measurement

An increasing reticulocyte concentration determined by quantification indicates only that the bone marrow is starting to respond to its stimulation. It does not show whether the new reticulocytes are of normal size, nor does it address their haemoglobin content. You need to measure the ‘quality’, i.e. the HGB content of these cells, as well. The XE-5000 can measure the haemoglobinisation of reticulocytes which can be used to assess iron deficiency and monitor its treatment. You can differentiate, for example, between non-functional and functional iron deficiencies.

  • Two PLT detection methods (impedance and fluorescence)

In the majority of samples, platelets are counted accurately by the impedance method. In some pathological samples, such as those with large platelets or red cell fragments, the fluorescence count is given priority as it reflects the RNA content and not only the size and is therefore more accurate. An automatic switching algorithm does this selection for you.

  • A meaningful assessment of thrombopoietic bone marrow activity (IPF)

The immature platelet fraction (IPF%) is reported as a percentage of the total platelet count. It provides a rapid indication of the platelet production status. The number of immature platelets found in peripheral blood is an indication for the rate of thrombopoiesis. Reactive bone marrow delivers an increased value of immature platelets. This information lets you distinguish whether thrombocytopenia is caused by bone marrow failure or an increased destruction or loss of platelets in the peripheral blood. Analysing the IPF% provides a second dimension of the platelet count.

Manage your information efficiently

Manage your information efficiently

The XE-5000’s intuitive software makes patient and sample information management significantly easier. All activities can now be carried out by staff of any level as defined in the system so you can enhance your flexibility. You define the layout of your software screens and so adapt the user interface to the needs of your laboratory.

To further simplify your daily QC results management, the use of XE-5000 and
e-CHECK (XE) also lets you access SNCS IQAS Online, Sysmex’s international external quality assurance system. This outstanding Internet-based external quality control service judges the performance of your analyser each day by comparing its quality control data to peer group data collected from other systems of the same type.

In addition, our work area management software  improves workflow flexibility and rule-based technical validation. It also covers areas of reagent management, QC data management and extended electronic data output.

System Expandability: Accelerate your workflow

System Expandability: Accelerate your workflow

We know the demands placed on haematology and the increasing cost and legislative pressure you’re feeling. We too have been in the business for forty years and more. Diagnostic demands, processing speed, and result quality are all decisive. The XE-5000 is the expert’s device of choice.

It is superb where it concerns throughput and total integration in automation concepts.

  • XE-Alpha N

Create a single tabletop instrument by combining the XE-5000 and an SP-1000i slide-maker/stainer via a rack interface system which increases the workflow efficiency of your lab.

  • HST-N and EXPERTline

Streamline your workflow by integrating your XE-5000 in a laboratory automation configuration. With the XE-5000 as the analytical core, it can be combined via a floor-standing conveyer system with a range of other components, such as the slide maker/stainer SP-1000i, an ESR analyser*, an HbA1c analyser*, plus a tube sorter (TS-series) and a reagent production unit (RPU-2100) for extra-high productivity.

*only available in certain countries

In the EXPERTline, XE-5000 features as the expert analyser component. Standardised sample and data management let you optimise your workload from a cost perspective. You can rapidly process both routine and special samples within the same timeframe. This means you can maximise your productivity as well as get your results to the clinician quickly. Good for your reputation, and good for the bottom line.  

Specifications

Specifications

The Case Manager is essentially based on the clinical value of the advanced clinical parameters and their combination.

 

The white blood cell differential is extended by additional parameters which offer support in a couple of serious clinical scenarios:

Detection or therapy monitoring of inflammations and infections (IG, NRBC, HFLC*)

Diagnosis of MDS (NEUT-X*)

Optimum timing for harvest of stem cells (HPC)

 

The extended red blood cell analysis includes a wide range of supporting parameters. These permit to take anaemia diagnostics to the differential level and aid in assessing therapy success:

Efficiency evaluation of erythropoiesis (RET-He , IRF, RPI*)

Therapy monitoring with anaemia of chronic diseases (RET-He)

Differential diagnosis of iron deficiency anaemia, haemolytic anaemia or thalassaemia

(RET-He, %HYPO-He*, %MicroR*, FRC*, RBC-He*, Delta-He*)

 

The extended platelet count includes a differential into mature and immature platelets, allowing better assessment of thrombocytopenic situations and support in the decision of how to proceed:

Differential diagnosis of thrombocytopenia and its probable reason: thrombopoietic

bone marrow failure or increased platelet consumption in the peripheral blood? (IPF)

 

Automated analysis of body fluids:

Cell counts (white and red cell counts, total nucleated cell count*)

for CSF, serous fluids, synovial fluids and expandable to others

Clinically useful information on possible inflammatory processes or infections

(PMN, MN, HF-BF*, TC-BF*, EO-BF*)

 

Throughput

up to 150 samples/h

 

Configurations

stand-alone or module of HST-N, XE-AMS or EXPERTline

 

*research parameters

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